Cox multivariate regression analysis indicated that serum AFP levels (p < 0.001), tumor size (p = 0.001), and PCSK9 levels (p = 0.049) were independently associated with OS, and serum AFP levels (p = 0.001), tumor number (p = 0.041), tumor size (p = 0.017), and PCSK9 expression level (p = 0.007) were independently associated with DFS (Table 2). The gene discussed is PCSK9; the disease is neoplasm.