After treatment with C75, Bcl-2 was downregulated, and Bax, cleaved Caspase9 and cleaved Caspase3 were upregulated in HCCLM3-PCSK9 cell lines, but no significant difference was detected in this apoptotic pathway between HCCLM3-Vector and HCCLM3-PCSK9 cells treated with C75, indicating that the FASN/Bax/Bcl-2/Caspase9/Caspase3 apoptosis pathway plays an important role in the regulation of HCC apoptosis by PCSK9. Here, PCSK9 is linked to hepatocellular carcinoma.