MAPT and major depressive disorder: In another study by Babulal et al. from Washington University that combined amyloid-PET and CSF amyloid biomarkers, a high CSF tau/Aβ42 ratio was associated with increased mood disturbance, anxiety and depression on the Profile of Mood States–Short Form (P = 0.005, 0.02 and 0.04 respectively), as well as with the NPI-Q total score (P = 0.003) at 1-year follow-up.