The longitudinal study of subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort [63] involved 115 cognitively normal subjects who were stratified into three groups: preclinical AD (with presence of both Aβ and tau pathologies), asymptomatic at risk of AD (amyloid or tau pathology present) and healthy controls. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.