Specifically, Wei F et al. found that PD-L1 promoted cancer stem cell (CSC) properties in colorectal cancer (CRC) [13], and PD-L1 also promoted cisplatin-resistance in non-small cell lung cancer (NSCLC) [14, 15], but no literatures reported the role of PD-L1 in regulating TMZ-resistance in GBM. This evidence concerns the gene CD274 and colorectal carcinoma.