Analysis of the normalized expression data from the 479 samples in TCGA melanoma cohort (RNA-seq) showed a clear positive correlation between the expression of MITF and ADAM10 with a Spearman coefficient of 0.34 (p = 1.44e− 14) and a Pearson coefficient of 0.37 (p = 6.57e− 17) (Fig. S5b). The gene discussed is ADAM10; the disease is melanoma.