Overproduction of some cytokines and growth factors secreted by BMSCs including Wnt inhibitors, interleukin-3 (IL-3), tumor necrosis factor alpha (TNF-a) and transforming growth factor b (TGF-b) is believed to be the most important factor contributing to osteoblast dysfunction in MM patients [11–13]. This evidence concerns the gene IL3 and Miyoshi myopathy.