The most commonly reported AEs of any grade were increased alanine aminotransferase (ALT) (21.6%), anemia (18.9%), increased aspartic aminotransferase (AST) (10.8%), and just 3 treatment-related AEs were recorded including ostealgia and eye edema up to grade 2 (Table S2 in the Online Resource). Here, GPT is linked to anemia (phenotype).