To identify clinically significant hub genes in the green module, we then performed LASSO Cox regression analysis and finally screened 7 genes: SPP2, G6PC, PLBD1, ETV4, PFKP, GNAZ, and ASRGL1. Then, a seven-gene risk scoring system was constructed, and this system successfully classified 417 HCC patients into two risk groups with significantly different survival rates. Here, SPP2 is linked to hepatocellular carcinoma.