Our observation is similar to that of Lin et al., who observed that baseline fasting glucose is correlated with the 4-year change in LVMI and is an independent predictor for LVMI and the occurrence of LVH after a 4-year follow-up in normotensive healthy elderly subjects without diabetes mellitus [25].Insulin itself could induce cardiovascular hypertrophy by acting on insulin growth factor receptors and simulating cell proliferation and lipid deposition [26, 27]. Here, INS is linked to diabetes mellitus.