BNP is a vasodilator and is crucial in preventing myocardial hypertrophy and fibrosis (Haworth, 2007; Tamura et al., 2000), so the increased BNP may act as a compensatory and adaptive mechanism to counteract the effects of these vasoconstrictors and to reduce ventricular hypertrophy. The gene discussed is NPPB; the disease is Ventricular hypertrophy.