C3 and tuberculosis: We found that TB-IRIS participants had increased levels of monocyte membrane-bound C1q (mC1q) (Fig 4D) and C3 (mC3) (Fig 4E) when compared to TB non-IRIS and non-TB, non-IRIS groups, post-ART (mC1q: TB-IRIS, median of 1.521 fold change [IQR: 1.376–1.724] vs TB non-IRIS 1.219 [IQR: 1.147–1.326] and mC3: TB-IRIS, median of 3.730 fold change [IQR: 2.445–4.952] vs TB non-IRIS 2.203 [IQR: 1.396–2.535]).