Controversial results observed in lung cancer with pooled HR = 0.73 (95%CI: 0.49–1.11 I2 = 0.0% p = 0.872) and subgroup analysis also showed GPRC5A expression predicted unfavorable prognosis in digestive system (HR: 2.32 95%CI: 1.73–3.11 I2 = 0.0% p = 0.479) (Fig 6), and other systems (HR: 1.29 95%CI:1.09–1.54 I2 = 77.2% p<0.000). This evidence concerns the gene GPRC5A and lung cancer.