High expression of GPRC5A was associated with Lymph node metastasis (OR:1.95, 95%CI 1.33–2.86, I2 = 43.9%, p = 0.129), advanced Tumor stage (OR: 1.83, 95%CI 1.15–2.92, I2 = 61.3%, p = 0.035), but not related to age (OR:1.14, 95%CI 0.86–1.52, I2 = 0.0%, p = 0.578), sex (OR 1.17, 95%CI 0.91–1.50, I2 = 0.0%, p = 0.863), differentiation (OR: 1.58, 95%CI 0.71–3.50, I2 = 88.5%, p<0.001), and distant metastasis (OR 1.40,95%CI0.59-3-32, I2 = 65.0%, p = 0.036). The gene discussed is GPRC5A; the disease is metastatic malignant neoplasm in the lymph nodes.