To assess the specific relationship between the GPRC5A and the OS of each cancer type, subgroup analysis showed high expression of GPRC5A was significantly associated with poor prognosis in the majority of solid cancers studied such as pancreatic, gastric, prostate, hepatocellular and esophageal cancer, but no significant effect was observed in colorectal and ovarian cancer. This evidence concerns the gene GPRC5A and esophageal cancer.