Three robust patterns were identified (Fig 6A–6C): genes, such as HSPA5, that were upregulated in DENV infection and downregulated in ZIKV and VEEV infections (Fig 6A); genes like NRBF2 that were upregulated only during ZIKV infection (Fig 6B); and genes, such as SERP1, that were downregulated only in VEEV infection (Fig 6C). Here, SERP1 is linked to Zika virus infectious disease.