Depletion of CXCL3, ATF3, TNFAIP3, and CXCL2, four out of five genes tested that positively correlated with vRNA abundance via viscRNA-Seq (orange bars), reduced VEEV-TC-83 infection by more than 40% as measured by luciferase assay 18 hpi with a nano-luciferase reporter TC-83 virus (VEEV-TC-83-nLuc) and normalized to cellular viability in two independent screens, suggesting that they are candidate proviral factors (Figs 5A, S4B and S4C). The gene discussed is CXCL3; the disease is infection.