Fig 9D shows that CJL females were not able to recover the second peak in IL-10 at any of the times tested. This means that CJL females did not produce as much pro-inflammatory cytokines (e.g. CT9, CT12) as controls. Compared to CJL males, CJL females produce less cytokines overall during acute inflammation. Males, however, lost their circadian gating of cytokines closer to CT0 (see Fig 9: CT21, CT0) and produced greater amounts of pro-inflammatory cytokines, making them more susceptible to sepsis at that time [91, 92]. The gene discussed is IL10; the disease is Sepsis.