Fig 7A shows that the loss of Rev-Erb leads to a loss of the second peak of IL-10, while the absence of Cry or Ror does not give rise to qualitatively different dynamics. As expected, a CT12 infection following Rev-Erb KO produces results similar to a CT0 infection (see Fig 5) because in both cases the concentration of the REV-ERB is at a minimum or even zero. Additionally, the damage marker is greatly reduced by the loss of Rev-Erb (Fig 7B). The gene discussed is CRYL1; the disease is infection.