Sox2, Oct4, and Bmi1 are effective markers of cancer stem cells, because they play important roles in the growth of cancer stem cells and promote the malignant progression of tumors.37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51. This evidence concerns the gene POU5F1 and cancer.