APOE and Alzheimer disease: To assess whether DNA and RNA fragments in aggregates are a random sampling from the genome and transcriptome, respectively, these nucleic acids were separately extracted from pooled aggregate preparations from either AD or age‐matched control (AMC) individuals (APOE ε3/ε4 heterozygotes; 3 subjects per group), and their sequences determined (UT Southwestern Genomics Core, Dallas TX).