Among them, the highly enriched pathways related to hematopoiesis were MAPK [21], insulin signaling pathway [2, 40], neurotrophin signaling pathway [18], Ras [27], FOXO [38], and mTOR signaling pathways [50], in addition to pathways involved in cancer especially AML and CML as shown in Fig. 3. This evidence concerns the gene BDNF and chronic myelogenous leukemia, BCR-ABL1 positive.