Recently, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) gefitinib, erlotinib, and AZD-92912 have been used to treat unresectable or recurrent lung cancer and have shown significantly improved clinical outcomes in patients with NSCLC with EGFR mutations (5-15). The gene discussed is EGFR; the disease is lung carcinoma.