In majority, metastatic endometrial endometrioid carcinoma from corpus uteri or lower uterine segment as non-HPV related often shows patchy p16 expression, relatively lower Ki-67 proliferation index and diffuse ER/PR/PAX8 expression.[6,8] On contrary, mucin-depleted usual-type ECA is more consistent with usual-type ECA. The gene discussed is MUC5AC; the disease is endometrial endometrioid carcinoma.