CCDC88A and cancer: This surgical approach has been leveraged to establish that G-protein regulation by GBA proteins, like GIV(a.k.a. Girdin) and DAPLE, is involved in normal physiological processes (e.g., formation of the neural tube during embryonic development), or in disease (e.g., cancer metastasis or birth defects) (Aznar et al., 2015; Garcia-Marcos et al., 2015; Ghosh, 2015; Leyme et al., 2017; Marivin et al., 2019).