The most common irAEs of any grade were (in order of frequency) diarrhea followed by hypothyroidism, elevated aspartate aminotransferase (AST), vitiligo, and elevated alanine aminotransferase (ALT), while the most common irAEs of grade ≥3 were elevated AST and ALT, pneumonia, diarrhea, and colitis.15 This evidence concerns the gene GPT and hypothyroidism.