Luciferase reporter plasmids containing full length of wild‐type RUNX2 or MREs mutated RUNX2 were co‐transfected with miR‐30a‐3p mimics into ccRCC cells, and luciferase assay was performed to examine the transcriptional level of the reporter gene. The gene discussed is RUNX2; the disease is nonpapillary renal cell carcinoma.