The melanoma cell lines A375, SK‐MEL2, and SK‐MEL28 expressed LRIG1 isoform A, whereas HaCaT keratinocytes and A431 cells expressed isoform B. The expression of different isoforms of LRIG1 in keratinocytes and melanocytes may refer to context‐specific functions, which might explain an oncogenic impact on tumorigenesis as well as tumor suppressor activity in other tissues [21, 22, 23, 24, 46]. The gene discussed is LRIG1; the disease is melanoma.