Therefore, to address whether reduced density/diameter of hippocampal capillaries could be sufficient for initiating Aβ plaque deposition, we injected ET1 or vehicle into hippocampal CA1 region in WT or AD mice aged 5 months old (Fig. 2a) when there are no Aβ plaques at this young age. The gene discussed is EDN1; the disease is Alzheimer disease.