EDN1 and Alzheimer disease: Likewise, the early Aβ plaque deposition in the hippocampus, initiated 7 days after the hippocampal injection of ET1 at 5 months old, was persistent up to 6 months old with the vehicle treatment, but that was partially prevented by the FA treatment, reduced to a level about 50% of the vehicle controls (Fig. 5e, f, AD, n = 20 (N = 7); AD-FA, n = 22 (N = 7); t = 2.987, df = 40, **P = 0.005.