Our previous efforts to address this need revealed that positron emission tomography (PET) imaging with [18F]PBR06, a radiotracer targeting translocator protein 18 kDa (TSPO) to detect microglial activation, discerned the reductive effect of LM11A-31 on neuroinflammation in the brains of multiple HD mouse models [16]. This evidence concerns the gene TSPO and Huntington disease.