Corroborating the current results, elevated plasma levels of IL-6 were reported in R6/2 and other HD mouse models, even at early to mid-symptomatic stages, and two other preclinical HD studies showed that potential therapies could normalize these levels highlighting the potential of plasma IL-6 as a translatable pharmacodynamic biomarker [81, 84, 85, 102, 128]. This evidence concerns the gene IL6 and Huntington disease.