Previous studies have shown that p75NTR-ecd levels are elevated in the urine of ALS patients and mouse models and altered in the blood (increased) and CSF (decreased) of Alzheimer’s disease patients and are thus being considered as prognostic and/or staging biomarkers in these diseases [21, 22, 87, 130]. This evidence concerns the gene NGFR and early-onset autosomal dominant Alzheimer disease.