Several diseases, including mood and anxiety disorders, have been shown to be associated with inflammation.33,34 It has been suggested that proinflammatory cytokines, including IL-6, might contribute to depression in susceptible individuals with disorders involving chronic inflammation.35,36 Roque et al. reported that IL-10 levels are related to depression.37 Therefore, inflammation might underlie the pathogeneses of PMS and major depressive disorder. This evidence concerns the gene IL6 and depressive disorder.