This is consistent with the result of lower IL-10 levels in the luteal phase than in the follicular phase among healthy women.26,29 According to Foster et al., this fluctuation among healthy women who show increased IL-10 levels after menstruation is considered a complex inflammatory process involving inflammatory cytokines.26 In the clinical setting, anti-inflammatory agents have been found to provide relief from some symptoms related to PMS, such as abdominal pain, back pain, irritability, tiredness, and bloating.30 Here, IL10 is linked to premenstrual tension.