We report a case of a two-year-old boy of Palestinian-Lebanese descent, with a history of raised immunoreactive trypsin test (IRT), positive sweat test, and phenotypical CF manifestations, found to have rare CF apparent homozygous <i>CFTR</i> (NM_000492.3) variant, c.3623del (p.Gly1208AlafsX3). The gene discussed is CFTR; the disease is cystic fibrosis.