Although rare, there are cases of genetic defects in ADH synthesis. These defects can be inherited as autosomal dominant, autosomal recessive, or X-linked recessive traits that can result in CDI. The inherited/familial causes account for 1% of CDI cases [5]. The specific gene mutation most commonly seen is the loss of the AVP gene located on chromosome 20p13 [6]. Here, AVP is linked to clostridium difficile infection.