However, among patients with NYHA class II, an inverse significant correlation was seen with r=-0.323, p=0.045, meaning thereby that low levels of vitamin D were associated with significantly higher NT-pro-BNP levels (Figure 2). NT-pro-BNP levels did not vary among patients with severe vitamin D deficiency (<15ng/ml) when compared to those with higher levels (15-30 ng/ml) [9172.5±10080 pg/ml vs 12685±13133pg/ml; p=0.174]. The gene discussed is NPPB; the disease is vitamin D deficiency.