Heparin has been reported to release hepatic triglyceride lipase (HTGL) from the liver and lipoprotein lipase (LPL) from the endothelial cells into the blood circulation.16) In turn, those lipases play a significant role in lipid metabolism by hydrolyzing triglycerides (TG) and phospholipids in circulating lipoproteins.17) The present study aimed to determine pre-heparin administration lipoprotein profiles at the onset of coronary arterial thrombosis (CAT) in patients with ST-segment elevation myocardial infarction (STEMI). The gene discussed is LPL; the disease is coronary thrombosis.