LGR5 and colorectal carcinoma: While LGR5 is commonly expressed/overexpressed in adenomas,48 expression is frequently low/absent in CRCs before re-expression in metastatic deposits;49 indeed, LGR5+ cells appear to be important in metastatic progression.58 As summarised by Morgan et al.,59 there is abundant contradictory data on the role of LGR5 in CRC.