While LGR5 is commonly expressed/overexpressed in adenomas,48 expression is frequently low/absent in CRCs before re-expression in metastatic deposits;49 indeed, LGR5+ cells appear to be important in metastatic progression.58 As summarised by Morgan et al.,59 there is abundant contradictory data on the role of LGR5 in CRC. This evidence concerns the gene LGR5 and adenoma.