LYZ and colitis: On the other hand, even though colonic epithelium contains no Paneth cell lineage, it has been reported that Paneth-derived lysozyme immunoactivity could be detected in colonic lumen.38 Several mouse genetic studies also demonstrate that Paneth cell depletion or defects in AMPs secretion cause increased susceptibility to DSS-induced colitis.17,18,39,40 Therefore, dysfunction of goblet cells and ablation of Paneth cells contribute to altered gut microbiome and colonic inflammation in Emc3ΔIEC mice.