Following orthologous transplant of Bax/Bak CRISPR/Cas9 edited MMTV-PyMT cells into WT recipients, tumours were allowed to grow to 5 mm diameter before treatment with MCL-1 inhibitor S63845 or vehicle control (Fig. 3A and Supplementary Figs. 2A and 3A). The gene discussed is BAK1; the disease is neoplasm.