BAK1 and neoplasm: Whilst we had shown that Mcl1 deletion can result in long-term tumour suppression (Fig. 1F), genetic deletion of Mcl1 had no effect on tumour growth in BAX/BAK-deficient tumours (Fig. 3C–E) and unlike BAX/BAK-proficient MMTV-PyMT tumours, decreased MCL-1 expression was still apparent in the context of BAX/BAK loss (Fig. 3F and Supplementary Fig. 3B–D) [16].