In 2D culture these tumour cell lines are however still dependent on pro-survival BCL-2 proteins as combined targeting of MCL-1 (genetically or pharmaceutically with S63845) and BCL-2/BCL-XL (with ABT737) resulted in high, but variable, levels of CD (Fig. 4B, also observed in an additional independently derived tumour cell line in Supplementary Fig. 4A). This evidence concerns the gene BCL2L1 and neoplasm.