More severe skin lesions (Fig. 6C) and higher bacterial load (Fig. 6D) was observed in the mice infected with the Newman parental strain than in those infected with the NewmanΔlgt mutant strain in both the SCID mice as well as the Balb/c controls, indicating that the innate immunity rather than the adaptive immunity plays an important role in contributing to the effect induced by Lpp in skin infection. This evidence concerns the gene LPP and skin infection.