Unexpectedly, neither a chemical inhibition of PDPK1 with 3 μM compound GSK 2334470 (IC50 ≈ 10 nM) nor a generated cancer cell line with an inducible KD of PDPK1 (> 90% KD) did mimic the phenotype of ERp57 KD. This evidence concerns the gene PDIA3 and cancer.