Among these proteins, several products delivered by activated macrophages, such as tumour necrosis factor (TNF), interleukin (IL)-1, IL-11, and Interferon-γ24, 25, as well as products derived from bacteria, such as lipopolysaccharide (LPS) associated with septicaemia, and modified lipoproteins such as oxidized LDL or lysophosphatidylcholine have been shown to inhibit LPL activity15, 21, 26. The gene discussed is TNF; the disease is bacterial infectious disease with sepsis.