CSF examination (Fig. 2) revealed five cases with abnormalities: anti-thyroid antibodies (anti-TG, TRAK, anti-TPO, and anti-TRAb) (#16&#77), COVID-19 (#111), neurosyphilis (#30), and twice OCBs type II and typical white matter lesions on brain MRI, that were diagnosed as multiple sclerosis (#49&51). This evidence concerns the gene TPO and neurosyphilis.