C3 and nervous system disorder: The network “Cellular assembly and organization, Neurological disease, Organismal development” was predicted with a high score for EAE-16d in IPA (Supplementary Fig. 2B) and involved the acute phase proteins HEMO (hemopexin, gene: HPX), A1AT (alpha-1-antitrypsin 1–1, gene: SERPINA1) and CO3 (complement 3, gene: C3).