The top 10 miRNAs that were upregulated after IFN-γ stimulation were MIR185, MIR1291, MIR339, MIR664-A, MIR377, MIR1248, MIR1306, MIR145, MIR15A, and MIR589. While the roles of these miRNAs have not been confirmed, we observed that their levels did not change significantly after IFN-γ stimulation, and that the miRNAs in AD-MSC-sEVs that significantly increased after IFN-γ stimulation were originally poorly expressed (Supplementary Fig. 7). The gene discussed is MIR1248; the disease is Alzheimer disease.