Although the secretion of insulin was similar among the four groups of mice, which was confirmed by fasting blood insulin levels and immunofluorescence staining for insulin in the pancreas (Fig. 1c and d), the homeostatic model assessment for insulin resistance (HOMA-IR) index and insulin resistance index were significantly increased in the KDR mice (Fig. 1e to g). The gene discussed is INS; the disease is Insulin resistance.