TP53 and human papilloma virus infection: Gene Ontology (GO) (Fig. 3B and C), widely used in functional annotation and enrichment analyses (17), and Kyoto Encyclopedia of Genes and Genomes (KEGG) (Fig. 3D and E) analysis revealed high enrichment of immune-related pathway (Fig. 3D and E, red squares), including GO terms such as “defense response to virus,” “immune system process,” and “innate immune response,” and pathways such as “human papillomavirus infection” and “p53 signaling.”