RIG-I-like receptors (RLRs): RIG-1, LGP2, and MDA-5 that sense viral infection (19) were found to be predominant in CD4+, CD8+, and CD14+ cell subsets at 5 dpv in goats and in CD4+ and CD14+ cell subsets of sheep (Fig. 4). Here, DHX58 is linked to viral infectious disease.