Previous studies showed that PKCα and its downstream effector FRA1 play key roles in driving CSCs of basal-like BC (27), implying that the AXL-PYK2-PKCα axis, which markedly affects FRA1 level/phosphorylation (Figs 2A and S3A and D), also regulates CSCs in TNBC. This evidence concerns the gene PRKCA and breast cancer.