ADA and Increased total eosinophil count: There were 15 unique IEI genes significantly associated with eosinophilia (BTK, CTLA4, PIK3CD, FOXP3, TNFRSR13B, MAGT1, RAG1, NLRP3, IFNGR1, ADA, NFKB2, CYBB, DOCK8, WAS STAT3), and 13 significantly associated with elevated IgE (CYBA, IFNGR1, NCF1, FOXP3, NCF2, ITGB2, CTL4, ADA, WAS, AIRE, CYBB, DOCK8, STAT3).