There were 15 unique IEI genes significantly associated with eosinophilia (BTK, CTLA4, PIK3CD, FOXP3, TNFRSR13B, MAGT1, RAG1, NLRP3, IFNGR1, ADA, NFKB2, CYBB, DOCK8, WAS STAT3), and 13 significantly associated with elevated IgE (CYBA, IFNGR1, NCF1, FOXP3, NCF2, ITGB2, CTL4, ADA, WAS, AIRE, CYBB, DOCK8, STAT3). The gene discussed is CYBB; the disease is Increased total eosinophil count.