When the patients were divided at different cut-off values, the mortality rate was 53% in patients with APACHE II score >15, and 83% in patients with APACHE II score >20 (Fig. 3), compatible with the findings of Horiuchi et al. Regarding ventilator and thrombomodulin use, these therapeutic choices were made in patients with severe conditions such as septic shock and DIC, which could have affected outcome in the mortality group. Here, THBD is linked to septic shock.