PRDX5 and malignant colon neoplasm: Although prior studies showed the CTD play a crucial role in colon cancer, breast cancer, and antineuroinflammation through target thioredoxin reductase, detyrosinated tubulin, and CDK2, respectively [26, 32, 33], we found that CTD could inhibit the proliferation of cancer cells by directly targeting AKT expression.