Relevant to the effect of MPH in Shank2- and Fmr1-deficient mice, hyperactivity of Trpm1-deficient mice may not be related to ADHD, but instead autism which is also one of the phenotypes of 15q13.3 microdeletion syndrome (Additional file 3: Table S1) [11, 43]. The gene discussed is TRPM1; the disease is attention deficit-hyperactivity disorder.