Previous studies demonstrated that the active substances mainly function by targeting the redox homeostasis and anti-oxidative stress pathways in the transgenic C. elegans AD model, and alleviate paralysis by increasing the activity of antioxidant enzymes, such as SOD and catalase, and upregulating the expression of daf-16, ctl-1, hsp-16.2, sod-3, and sir-2.1 [49, 54, 55, 57–59]. The gene discussed is SOD3; the disease is Alzheimer disease.