INS and type 2 diabetes mellitus: Specifically, Lyplal1 has been associated with type 2 diabetes [57] including through the use of first-phase insulin secretion as a marker to identify candidate interacting SNPs [58], and male mice with genetic deletion of ABHD17a and ABHD17c, but not ABHD17b, have improved glucose tolerance, and males lacking ABHD17a also have decreased circulating insulin levels (mousephenotype.org).