Moreover, both global Kcnma1 deletion in mice, as well as inducible conditional genetic deletion of Kcnma1 in adult mouse adipocytes, prevents excessive body weight gain and fat deposition in response to a high-fat diet, revealing an important role for adipocyte BK channels in controlling obesity [97]. This evidence concerns the gene KCNMA1 and obesity due to melanocortin 4 receptor deficiency.