Using the cancer genome atlas (TCGA) and the cBioPortal database to trace cancer mutations in different HLA types (HLA-A, HLA-B, and HLA-C; figures 1 and 2) suggests that even though there are similarities between HLA types, several mutations occur only in a particular HLA molecule and in the α3 domain and the transmembrane domains [13]. Here, HLA-A is linked to cancer.