A higher κ/λ LC ratio, i.e. a predominance of Igκ, has been observed for anti-granulocyte colony-stimulating factor antibodies [35], non-specific IgG antibodies in mixed connective tissue disease [36] and for CD10+ B cells in Hashimoto thyroiditis (HT) [37]. The gene discussed is MME; the disease is Hashimoto thyroiditis.